ASUS Prime X399-A DDR4 AMD Motherboard
MPN ASUS-PRIME-X399-A · Brand ASUS · E-ATX
The ASUS Prime X399-A is an E-ATX motherboard for AMD Ryzen Threadripper TR4 processors, supporting up to 128GB quad-channel DDR4, dual NVMe M.2, USB 3.1 Gen 2, and multi-GPU configurations
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Overview
The ASUS Prime X399-A is an Extended ATX (E-ATX) motherboard built on the AMD X399 chipset, designed for AMD Ryzen Threadripper processors using the TR4 socket. It is engineered for professional content creators, power users, and enthusiasts who demand extreme multi-threaded performance and comprehensive platform flexibility. At the heart of its memory subsystem, the Prime X399-A supports up to 128GB of DDR4 memory in quad-channel configuration, with compatibility for kits rated up to DDR4-3600MHz. This broad memory bandwidth ceiling makes it well-suited for video editing, 3D rendering, and data-intensive workloads. The board includes two M.2 slots capable of NVMe drives at up to 32Gbps via x4 PCIe 3.0 bandwidth, and a U.2 connector that equally supports NVMe speeds up to 32Gbps, enabling flexible, high-speed storage configurations without sacrificing PCIe expansion slots. Connectivity is further enhanced by onboard USB 3.1 Gen 2 Type-A and Type-C ports delivering up to 10Gbps data transfer, along with a front-panel USB 3.1 Gen 2 header. For graphics, the board supports both NVIDIA SLI and AMD CrossFireX in 2-way or 3-way configurations via PCIe x16 and x4 slots. The ASUS 5-Way Optimisation feature combines Auto-Tuning and Fan Xpert 4 to automate overclocking profiles and cooling fan curves, adapting dynamically to CPU and GPU workload demands. The dedicated ASUS Pro Clock technology provides a base-clock generator to extend CPU and memory overclocking margins beyond standard limits. Thermal management is further supported by an M.2 heatsink reported to reduce SSD temperatures by up to 20°C under load. Audio is handled by the Realtek S1220A codec, co-developed with Realtek, featuring a 120dB signal-to-noise ratio on the stereo line-out and 113dB SNR on line-in. An impedance-sensing circuit automatically adjusts headphone gain for optimal output. Personalisation options include ASUS AURA Sync RGB lighting with two additional RGB headers and 3D-printing-friendly mounting points. The reinforced Safe Slot PCIe design uses an injection-moulded metal frame to anchor heavyweight GPUs securely. **Verified Specifications:** - Form Factor: Extended ATX (E-ATX) - Socket: AMD TR4 (Ryzen Threadripper) - Chipset: AMD X399 - Memory: Up to 128GB DDR4, quad-channel, up to DDR4-3600MHz - Storage: Dual M.2 (NVMe, up to 32Gbps); U.2 connector (up to 32Gbps) - USB: USB 3.1 Gen 2 Type-A and Type-C (10Gbps) - Audio Codec: Realtek S1220A — 120dB SNR line-out, 113dB SNR line-in - GPU Support: NVIDIA SLI and AMD CrossFireX (2/3-way) - Product Dimensions: 30.48 x 25.55 cm; Weight: ~2.04 kg - Included: SLI HB Bridge (2-Way-M), M.2 vertical bracket, M.2 screw package, ASUS Q-Shield, 4× SATA 6Gbps cables, Q-Connector, User's Manual, Supporting DVD
Datasheet
| Form Factor | E-ATX |
|---|---|
| Series | PRIME X399-A |
| Wattage | 140 |
| Item Width | 1 Inches |
| Item Height | 10.06 Inches |
| Item Weight | 2 kg 40 g |
| Manufacturer | ASUS Computer International Direct |
| Wireless Type | 802.11a |
| Item Model Number | PRIME X399-A |
| Product Dimensions | 30.48 x 2.54 x 25.55 cm; 2.04 Kilograms |
| Included Components | SLI HB BRIDGE(2-WAY-M), PRIME X399-A motherboard, M.2 vertical bracket, M.2 Screw Package, ASUS Q-Shield, Supporting DVD, User's manual, Q-connector, Serial ATA 6.0Gb/s cables(4) |
| Are Batteries Included | Yes |
| Graphics Card Interface | PCI-Express x4, PCI-Express x16 |
| Number Of USB 2.0 Ports | 1 |
| Number Of Lithium Ion Cells | 1 |
| Number Of Lithium Metal Cells | 1 |
| Lithium Battery Energy Content | 0.63 Watt Hours |
| Socket | AMD â€" AM3+ |




